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Year Number of Results
1966 4
1967 1
1968 4
1969 1
1970 1
1974 1
1982 1
1985 1
1986 1
1989 1
1990 1
1991 1
1992 1
1993 1
1994 3
1995 3
1996 3
1997 1
2001 1
2002 1
2003 2
2004 3
2005 1
2006 2
2007 2
2008 1
2010 1
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2013 1
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2020 1
2024 0

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48 results

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Page 1
2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter.
Hiranita T, Wilkinson DS, Hong WC, Zou MF, Kopajtic TA, Soto PL, Lupica CR, Newman AH, Katz JL. Hiranita T, et al. J Pharmacol Exp Ther. 2014 May;349(2):297-309. doi: 10.1124/jpet.113.212738. Epub 2014 Feb 11. J Pharmacol Exp Ther. 2014. PMID: 24518035 Free PMC article.
The present study examined RTI-371 [3beta-(4-methylphenyl)-2beta-[3-(4-chlorophenyl)-isoxazol-5-yl]tropane], a phenyltropane cocaine analog with effects distinct from cocaine, and assessed potential mechanisms for those effects by comparison with its constitutional …
The present study examined RTI-371 [3beta-(4-methylphenyl)-2beta-[3-(4-chlorophenyl)-isoxazol-5-yl]tropane], a phenyltropane cocaine …
Highly potent cocaine analogs cause long-lasting increases in locomotor activity.
Fleckenstein AE, Kopajtic TA, Boja JW, Carroll FI, Kuhar MJ. Fleckenstein AE, et al. Eur J Pharmacol. 1996 Sep 12;311(2-3):109-14. doi: 10.1016/0014-2999(96)00423-2. Eur J Pharmacol. 1996. PMID: 8891589
Three cocaine analogs were compared with cocaine for the capacity to affect: (1) dopamine transporter binding and function; and (2) locomotor activity. ...Parallel line analysis indicated that the slopes of the ascending portion of the RTI-121 and RTI-130 dose-respo …
Three cocaine analogs were compared with cocaine for the capacity to affect: (1) dopamine transporter binding and function; an …
Discriminative stimulus properties of cocaine: enhancement by beta-adrenergic receptor antagonists.
Kleven MS, Koek W. Kleven MS, et al. Psychopharmacology (Berl). 1997 Jun;131(3):307-12. doi: 10.1007/s002130050297. Psychopharmacology (Berl). 1997. PMID: 9203242
Although many of the behavioral effects of cocaine are widely believed to be mediated by blockade of dopamine transporters, recent studies suggest that norepinephrine (NE) may play a modulatory role. In this study, selective and nonselective beta-adrenergic receptor antago …
Although many of the behavioral effects of cocaine are widely believed to be mediated by blockade of dopamine transporters, recent st …
alpha(2) Adrenergic and imidazoline receptor agonists prevent cue-induced cocaine seeking.
Smith RJ, Aston-Jones G. Smith RJ, et al. Biol Psychiatry. 2011 Oct 15;70(8):712-719. doi: 10.1016/j.biopsych.2011.06.010. Epub 2011 Jul 23. Biol Psychiatry. 2011. PMID: 21783176 Free PMC article.
METHODS: Rats were tested for reinstatement of drug seeking following cocaine self-administration and extinction. We first evaluated the effects of clonidine, an agonist at alpha(2) and imidazoline-1 (I(1)) receptors, on relapse to cocaine seeking. ...RESULTS: We fo …
METHODS: Rats were tested for reinstatement of drug seeking following cocaine self-administration and extinction. We first evaluated …
Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging.
Lindsey KP, Wilcox KM, Votaw JR, Goodman MM, Plisson C, Carroll FI, Rice KC, Howell LL. Lindsey KP, et al. J Pharmacol Exp Ther. 2004 Jun;309(3):959-69. doi: 10.1124/jpet.103.060293. Epub 2004 Feb 24. J Pharmacol Exp Ther. 2004. PMID: 14982963
The dopamine transporter (DAT) is a critical recognition site for cocaine and contributes to its significant abuse liability. Accordingly, the development of compounds that target the DAT represents a logical approach in the pharmacological treatment of cocaine abus …
The dopamine transporter (DAT) is a critical recognition site for cocaine and contributes to its significant abuse liability. Accordi …
Cluster headache: symptomatic treatment.
Torelli P, Manzoni GC. Torelli P, et al. Neurol Sci. 2004 Oct;25 Suppl 3:S119-22. doi: 10.1007/s10072-004-0267-7. Neurol Sci. 2004. PMID: 15549518
Sumatriptan nasal spray, zolmitriptan and dihydroergotamine nasal spray are scarcely effective. After the introduction of sumatriptan, ergotamine tartrate has been relegated to a secondary role in the symptomatic treatment of CH. Among other non-drug and topical drug treat …
Sumatriptan nasal spray, zolmitriptan and dihydroergotamine nasal spray are scarcely effective. After the introduction of sumatriptan, ergot …
Nicotine administration effects on feeding and cocaine-amphetamine-regulated transcript (CART) expression in the hypothalamus.
Kramer PR, Kramer SF, Marr K, Guan G, Wellman PJ, Bellinger LL. Kramer PR, et al. Regul Pept. 2007 Feb 1;138(2-3):66-73. doi: 10.1016/j.regpep.2006.08.002. Epub 2006 Sep 18. Regul Pept. 2007. PMID: 16979766
In previous studies food intake and meal size significantly decreased in rats two days after injecting 4 mg/kg/day nicotine tartrate. Food intake returned to normal after nine days of continued nicotine treatment, when reduced meal size is countered by an increase in meal …
In previous studies food intake and meal size significantly decreased in rats two days after injecting 4 mg/kg/day nicotine tartrate. …
Gateways to clinical trials.
Tomillero A, Moral MA. Tomillero A, et al. Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):331-88. doi: 10.1358/mf.2010.32.5.1520420. Methods Find Exp Clin Pharmacol. 2010. PMID: 20664824 Free article.
[11C]RAC; (18)F-Fluoromisonidazole; 89-12; 9-[18F]Fluoropropyl-(+)-dihydrotetrabenazine; Adalimumab, Adecatumumab, ADMVA, ADXS-11-001, Aflibercept, Agatolimod sodium, AGS-004, Alglucosidase alfa, Aliskiren fumarate, Alvocidib hydrochloride, AMG-108, AMG-853, Apixaban, Aripiprazol …
[11C]RAC; (18)F-Fluoromisonidazole; 89-12; 9-[18F]Fluoropropyl-(+)-dihydrotetrabenazine; Adalimumab, Adecatumumab, ADMVA, ADXS-11-001, Aflib …
Causes of differential cardiovascular sensitivity to cocaine. I: Studies in conscious rats.
Branch CA, Knuepfer MM. Branch CA, et al. J Pharmacol Exp Ther. 1994 May;269(2):674-83. J Pharmacol Exp Ther. 1994. PMID: 8182535
Cocaine produces apparent myocardial ischemia in some individuals without deleterious effects in others. The authors identified a subset of rats in which cocaine produces a decrease in cardiac output and an increase in cardiomyopathies. ...
Cocaine produces apparent myocardial ischemia in some individuals without deleterious effects in others. The authors identified a sub …
Food deprivation history and cocaine self-administration: an animal model of binge eating.
Specker SM, Lac ST, Carroll ME. Specker SM, et al. Pharmacol Biochem Behav. 1994 Aug;48(4):1025-9. doi: 10.1016/0091-3057(94)90215-1. Pharmacol Biochem Behav. 1994. PMID: 7972280
Each time the DEPR group was food deprived, they were allowed to recover to normal weight. They were then injected with butorphanol tartrate (BUTR), an opioid that stimulates feeding, and food intake was measured for 4 h. ...In the second part of the experiment, an autosha …
Each time the DEPR group was food deprived, they were allowed to recover to normal weight. They were then injected with butorphanol tartr …
48 results